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Bethyl Laboratories
BLM Polyclonal Antibody
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FIGURE: 1 / 1
BLM Antibody (A300-570A) in IP
Detection of mouse BLM by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 1/4 of IP loaded) from mouse NIH 3T3 cells. Antibodies: Affinity purified rabbit anti-BLM antibody (Product # A300-570A) (lot 1) used for IP at 3 µg/mg lysate. BLM was also immunoprecipitated using rabbit anti-BLM antibodies BL2689 and A300-572A at 3 µg/mg lysate. Immunoprecipitated BLM was blotted using A300-572A at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A300-570A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 1 and 50 of mouse Bloom Syndrome Homolog.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bloom syndrome homolog; Bloom syndrome protein homolog; DNA 3'-5' helicase BLM; mBLM; MGC126616; MGC131618; MGC131620; RecQ helicase homolog; RecQ-like DNA helicase BLM
Gene Aliases: Blm
UniProt ID: (Mouse) O88700
Entrez Gene ID: (Mouse) 12144
nucleotide binding
bubble DNA binding
p53 binding
nucleic acid binding
DNA binding
single-stranded DNA binding
catalytic activity
ATP-dependent DNA helicase activity
helicase activity
protein binding
ATP binding
ATP-dependent helicase activity
four-way junction helicase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ATPase activity
annealing helicase activity
ATP-dependent 3'-5' DNA helicase activity
G-quadruplex DNA binding
DNA helicase
regulation of cyclin-dependent protein serine/threonine kinase activity
telomere maintenance
DNA double-strand break processing
DNA strand renaturation
DNA replication
DNA repair
DNA recombination
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
response to X-ray
replication fork processing
DNA duplex unwinding
cellular metabolic process
positive regulation of transcription, DNA-templated
negative regulation of DNA recombination
negative regulation of mitotic recombination
alpha-beta T cell differentiation
positive regulation of alpha-beta T cell proliferation
regulation of binding
protein oligomerization
chromosome organization
negative regulation of cell division
negative regulation of thymocyte apoptotic process
cellular response to ionizing radiation
cellular response to hydroxyurea
cellular response to camptothecin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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