Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 3; Biogenesis of lysosome-related organelles complex 1 subunit 3; biogenesis of lysosome-related organelles complex-1, subunit 3; BLOC-1 subunit 3; reduced pigmentation, mouse, homolog of
Gene Aliases: BLOC1S3; BLOS3; HPS8; RP
UniProt ID: (Human) Q6QNY0
Entrez Gene ID: (Human) 388552
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