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Product Details
PA5-65597
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human BLOC1S3. Recombinant protein control fragment (Product #RP-106259).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2663726
Product Specific Information
Immunogen sequence: LPPLVVQRESA EEAWGTEEAP APAPARSLLQ LRLAES
Highest antigen sequence identity to the following orthologs - mouse 84%, rat 84%.
Target Information
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 3; Biogenesis of lysosome-related organelles complex 1 subunit 3; biogenesis of lysosome-related organelles complex-1, subunit 3; BLOC-1 subunit 3; reduced pigmentation, mouse, homolog of
Gene Aliases: BLOC1S3; BLOS3; HPS8; RP
UniProt ID: (Human) Q6QNY0
Entrez Gene ID: (Human) 388552
eye development
anterograde axonal transport
platelet activation
neuron projection development
melanosome transport
melanosome organization
positive regulation of natural killer cell activation
secretion of lysosomal enzymes
endosome to melanosome transport
response to drug
pigmentation
anterograde synaptic vesicle transport
platelet dense granule organization
protein transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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