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Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Suggested positive control: antigen standard for ARNTL (transient overexpression lysate), reticulocyte lysate.
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
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Protein Aliases: ARNT-like protein 1, brain and muscle; Arnt3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic helix-loop-helix ARNT-like protein 1; basic-helix-loop-helix-PAS orphan MOP3; Basic-helix-loop-helix-PAS protein MOP3; bHLH-PAS protein JAP3; bHLHe5; Brain and muscle ARNT-like 1; CG8727 PA; Class E basic helix-loop-helix protein 5; cycle; Member of PAS protein 3; member of PAS superfamily 3; MGC47515; PAS domain-containing protein 3; testis tissue sperm-binding protein Li 50e; Tic
Gene Aliases: Arnt3; ARNTL; BHLHE5; BMAL1; BMAL1b; bmal1b'; BMAL1c; JAP3; MOP3; PASD3; TIC
UniProt ID: (Human) O00327, (Rat) Q9EPW1, (Mouse) Q9WTL8
Entrez Gene ID: (Human) 406, (Rat) 29657, (Mouse) 11865
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