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Invitrogen
BMP-5 Polyclonal Antibody
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BMP-5 Antibody (PA5-47821) in IHC (F)
Immunohistochemical analysis of BMP-5 in immersion fixed frozen sections of mouse embryo (13 d.p.c.). Samples were incubated in BMP-5 polyclonal antibody (Product # PA5-47821) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to developing brain and musc... View More
Product Details
PA5-47821
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant mouse BMP-5 Ala315-His452
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, approximately 20% cross-reactivity with recombinant human BMP-5 is observed. In direct ELISAs, approximately 100% cross-reactivity with recombinant human BMP-5 is observed, and approximately 4% cross-reactivity with recombinant mouse (rm) BMP-6 and rmBMP-7 is observed, and less than 1% cross-reactivity with rmBMP-8b is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lungs and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP 5; BMP-5; Bone morphogenetic protein; Bone morphogenetic protein 5; MGC34244; short ear
Gene Aliases: AU023399; Bmp-5; Bmp5; se
UniProt ID: (Mouse) P49003
Entrez Gene ID: (Mouse) 12160
skeletal system development
ossification
type B pancreatic cell development
multicellular organism development
pattern specification process
negative regulation of cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of steroid biosynthetic process
cell differentiation
BMP signaling pathway
male genitalia development
negative regulation of aldosterone biosynthetic process
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
cell development
positive regulation of epithelial cell proliferation
cartilage development
SMAD protein signal transduction
positive regulation of dendrite development
negative regulation of cortisol biosynthetic process
positive regulation of DNA-dependent DNA replication
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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