This antibody detects recombinant human and mouse BMP-6 in direct ELISAs and mouse BMP-6 in Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) BMP-5 and rmBMP-7 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMP-6; Bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-related protein; Vg1-related sequence; VGR; VGR-1; VGR1
Gene Aliases: Bmp-6; Bmp6; D13Wsu115e; Vgr1
UniProt ID: (Mouse) P20722
Entrez Gene ID: (Mouse) 12161