Peptide sequence: QGKHNSAPMF MLDLYNAMAV EEGGGPGGQG FSYPYKAVFS TQGPPLASLQ
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 91%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 82%
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.
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Protein Aliases: BMP; BMP-7; Bone morphogenetic protein; Bone morphogenetic protein 7; Eptotermin alfa; OP-1; Osteogenic protein 1; RP11-560A15.5
Gene Aliases: BMP7; OP-1; OP1
UniProt ID: (Human) P18075
Entrez Gene ID: (Human) 655