Invitrogen

BMP-7 Polyclonal Antibody

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BMP-7 Polyclonal Antibody

Product Details

PA5-87488

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 70-251 of BMP7 (NP_0017101)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.65 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804193

Product Specific Information

Immunogen sequence: PHLQGKHNSA PMFMLDLYNA MAVEEGGGPG GQGFSYPYKA VFSTQGPPLA SLQDSHFLTD ADMVMSFVNL VEHDKEFFHP RYHHREFRFD LSKIPEGEAV TAAEFRIYKD YIRERFDNET FRISVYQVLQ EHLGRESDLF LLDSRTLWAS EEGWLVFDIT ATSNHWVVNP RHNLGLQLSV ET

Positive Samples: MCF-7, Mouse kidney

Target Information

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BMP; BMP-7; bone moorphogenic protein-7; Bone morphogenetic protein; Bone morphogenetic protein 7; OP-1; Osteogenic protein 1; RP11-560A15.5

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Gene Aliases: BMP-7; BMP7; OP-1; OP1

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UniProt ID: (Human) P18075, (Mouse) P23359

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Entrez Gene ID: (Human) 655, (Mouse) 12162, (Rat) 85272

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Function(s)
cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding BMP receptor binding growth factor
Process(es)
skeletal system development ossification metanephros development ureteric bud development mesoderm formation mesonephros development epithelial to mesenchymal transition axon guidance embryonic pattern specification negative regulation of striated muscle cell apoptotic process positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation dendrite development embryonic limb morphogenesis positive regulation of bone mineralization BMP signaling pathway epithelial cell differentiation negative regulation of NF-kappaB transcription factor activity response to estradiol response to vitamin D positive regulation of heterotypic cell-cell adhesion protein localization to nucleus growth negative regulation of phosphorylation negative regulation of NF-kappaB import into nucleus odontogenesis of dentin-containing tooth regulation of apoptotic process positive regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity response to peptide hormone negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of Notch signaling pathway negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube mesenchymal cell differentiation neuron projection morphogenesis cartilage development embryonic skeletal joint morphogenesis regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction branching involved in salivary gland morphogenesis mesenchyme development negative regulation of cell death negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis monocyte aggregation cellular response to hypoxia cellular response to BMP stimulus negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis negative regulation of glomerular mesangial cell proliferation metanephric mesenchyme morphogenesis nephrogenic mesenchyme morphogenesis metanephric mesenchymal cell proliferation involved in metanephros development positive regulation of dendrite development positive regulation of hyaluranon cable assembly regulation of removal of superoxide radicals eye development kidney development multicellular organism development pattern specification process salivary gland morphogenesis negative regulation of cell proliferation organ morphogenesis positive regulation of cell death cell differentiation tube morphogenesis regulation of phosphorylation regulation of MAPK cascade positive regulation of cell differentiation positive regulation of neuron differentiation cell development camera-type eye morphogenesis anatomical structure formation involved in morphogenesis negative regulation of neurogenesis
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