Search
Invitrogen
BMP-8 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-103111
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BMP8B(Accession P34820), corresponding to amino acid residues P267-D317.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total BMP8B.
Target Information
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: BMP; BMP-8; BMP-8A; BMP-8B; Bone morphogenetic protein; bone morphogenetic protein 8 (osteogenic protein 2); Bone morphogenetic protein 8A; Bone morphogenetic protein 8B; MGC131757; OP-2; Osteogenic protein 2; unnamed protein product
Gene Aliases: Bmp-8; Bmp7r1; BMP8; BMP8A; BMP8B; OP-2; OP2; Op3
UniProt ID: (Human) Q7Z5Y6, (Human) P34820, (Mouse) P34821, (Mouse) P55105
Entrez Gene ID: (Human) 353500, (Human) 656, (Mouse) 12163, (Mouse) 12164
ossification
diet induced thermogenesis
cell differentiation
BMP signaling pathway
developmental process
negative regulation of insulin secretion
cartilage development
energy homeostasis
skeletal system development
negative regulation of cell differentiation
osteoblast differentiation
transforming growth factor beta receptor signaling pathway
multicellular organism development
germ cell development
spermatogenesis
positive regulation of pathway-restricted SMAD protein phosphorylation
growth
regulation of apoptotic process
regulation of MAPK cascade
SMAD protein signal transduction
regulation of energy homeostasis
embryonic morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support