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Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
BMP10 Fusion Protein Ag18746 (154-333 aa encoded by BC105063) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.13 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: DRMIYDGVD RKITIFEVLE SKGDNEGERN MLVLVSGEIY GTNSEWETFD VTDAIRRWQK SGSSTHQLEV HIESKHDEAE DASSGRLEID TSAQNKHNPL LIVFSDDQSS DKERKEELNE MISHEQLPEL DNLGLDSFSS GPGEEALLQM RSNIIYDSTA RIRRNAKGNY CKRTPLYIDF K (154-333 aa encoded by BC105063)
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMP; BMP-10; Bone morphogenetic protein; Bone morphogenetic protein 10
Gene Aliases: BMP10
UniProt ID: (Human) O95393
Entrez Gene ID: (Human) 27302
Molecular Function:
growth factor
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