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          • Primary Antibodies ›
          • BMP-2 Antibodies

          Fabgennix

          BMP2 Polyclonal Antibody, Biotin

          View all (51) BMP-2 antibodies

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          Cite BMP2 Polyclonal Antibody, Biotin

          Additional Information:
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          BMP2 Polyclonal Antibody, Biotin

          Product Details

          BMP2-BIOTIN

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunohistochemistry (IHC)

          1:50-1:250
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:250
          -

          ELISA (ELISA)

          1:10,000
          -

          Immunoprecipitation (IP)

          1:50-1:250
          -

          Immunomicroscopy (IM)

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Non-human primate, Pig

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to Mouse BMP2 amino acid region 45-60 conjugated to Keyhole Limpet Haemocyanin (KLH). Sequence:SEDVLSEFELRLLSMF
          View immunogen

          Conjugate

          Biotin Biotin Biotin

          Form

          Liquid

          Concentration

          0.5-1.5 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP; BMP-2; BMP-2A; BMPR-II; BMPRII; Bone morphogenetic; Bone morphogenetic protein; Bone morphogenetic protein 2; Bone morphogenetic protein 2A; H-BMP-2; morphogen; osteogenic protein 2

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          Gene Aliases: AI467020; BDA2; Bmp-2; BMP2; BMP2A; SSFSC; SSFSC1

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          UniProt ID: (Human) P12643, (Mouse) P21274

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          Entrez Gene ID: (Human) 650, (Pig) 100157103, (Mouse) 12156

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          Function(s)
          receptor binding cytokine activity protein binding growth factor activity phosphatase activator activity co-receptor binding protein serine/threonine kinase activator activity receptor agonist activity BMP receptor binding retinol dehydrogenase activity transforming growth factor beta receptor binding protein domain specific binding protein homodimerization activity SMAD binding protein heterodimerization activity growth factor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter skeletal system development ossification osteoblast differentiation branching involved in ureteric bud morphogenesis response to hypoxia in utero embryonic development epithelial to mesenchymal transition positive regulation of protein phosphorylation chondrocyte differentiation myeloid leukocyte differentiation heart morphogenesis heart induction endodermal-mesodermal cell signaling aortic valve development atrioventricular valve morphogenesis endocardial cushion morphogenesis cardiac atrium formation endocardial cushion formation positive regulation of extracellular matrix constituent secretion proteoglycan metabolic process regulation of transcription, DNA-templated transcription from RNA polymerase II promoter inflammatory response Notch signaling pathway cell-cell signaling heart development positive regulation of cell proliferation negative regulation of cell proliferation response to bacterium organ morphogenesis gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of steroid biosynthetic process positive regulation of phosphatase activity telencephalon development telencephalon regionalization negative regulation of cell-cell adhesion cell differentiation positive regulation of Wnt signaling pathway bone mineralization osteoclast differentiation positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of epithelial cell differentiation protein destabilization negative regulation of aldosterone biosynthetic process positive regulation of osteoblast proliferation cardiocyte differentiation embryonic heart tube anterior/posterior pattern specification positive regulation of peroxisome proliferator activated receptor signaling pathway ameloblast differentiation odontogenesis of dentin-containing tooth positive regulation of odontogenesis regulation of odontogenesis of dentin-containing tooth positive regulation of apoptotic process positive regulation of MAPK cascade negative regulation of insulin-like growth factor receptor signaling pathway cell fate commitment positive regulation of cell differentiation negative regulation of fat cell differentiation positive regulation of fat cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle cell proliferation astrocyte differentiation positive regulation of astrocyte differentiation mesenchymal cell differentiation inner ear development negative regulation of calcium-independent cell-cell adhesion negative regulation of muscle cell differentiation cartilage development cardiac muscle cell differentiation cardiac muscle tissue morphogenesis pericardium development corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation cardiac epithelial to mesenchymal transition bone development positive regulation of SMAD protein import into nucleus lung vasculature development mesenchyme development muscle tissue development positive regulation of cartilage development positive regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to BMP stimulus mesenchymal cell proliferation involved in ureteric bud development negative regulation of canonical Wnt signaling pathway positive regulation of bone mineralization involved in bone maturation positive regulation of p38MAPK cascade positive regulation of odontoblast differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter cardiac jelly development atrioventricular canal morphogenesis negative regulation of cortisol biosynthetic process regulation of cardiac muscle cell differentiation negative regulation of cardiac muscle cell differentiation activation of MAPK activity positive regulation of endothelial cell proliferation BMP signaling pathway involved in heart induction negative regulation of Wnt signaling pathway involved in heart development protein phosphorylation transforming growth factor beta receptor signaling pathway multicellular organism development embryo development positive regulation of pathway-restricted SMAD protein phosphorylation bone mineralization involved in bone maturation growth regulation of apoptotic process regulation of MAPK cascade cell development positive regulation of neurogenesis oxidation-reduction process pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction positive regulation of Wnt signaling pathway by BMP signaling pathway cellular response to organic cyclic compound positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
          It has to be done as per old AB suggested Products section.

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