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Invitrogen
BMP6 Polyclonal Antibody
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FIGURE: 1 / 1
BMP6 Antibody (PA5-97012) in WB
Western blot analysis of BMP6 in extracts of various cell lines. Samples were incubated with BMP6 Polyclonal antibody (Product # PA5-97012) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-97012
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 375-513 of human BMP6 (NP_0017091)
Conjugate
Form
Liquid
Concentration
1.05 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: DU145, Mouse lung, Mouse kidney, Mouse heart, Rat brain, Rat kidney
Immunogen sequence: SASSRRRQQS RNRSTQSQDV ARVSSASDYN SSELKTACRK HELYVSFQDL GWQDWIIAPK GYAANYCDGE CSFPLNAHMN ATNHAIVQTL VHLMNPEYVP KPCCAPTKLN AISVLYFDDN SNVILKKYRN MVVRACGCH
Target Information
BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP 6; BMP-6; Bone morphogenetic protein; Bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR-1
Gene Aliases: Bmp-6; BMP6; D13Wsu115e; VGR; VGR1
UniProt ID: (Human) P22004, (Mouse) P20722, (Rat) Q04906
Entrez Gene ID: (Human) 654, (Mouse) 12161, (Rat) 25644
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
eye development
kidney development
positive regulation of endothelial cell proliferation
endochondral ossification
type B pancreatic cell development
cellular iron ion homeostasis
inflammatory response
immune response
positive regulation of pathway-restricted SMAD protein phosphorylation
response to activity
positive regulation of bone mineralization
BMP signaling pathway
male genitalia development
positive regulation of lipopolysaccharide-mediated signaling pathway
response to magnesium ion
positive regulation of chondrocyte differentiation
positive regulation of aldosterone biosynthetic process
response to retinoic acid
growth
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of endothelial cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
positive regulation of protein secretion
cartilage development
response to glucocorticoid
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
multicellular organismal iron ion homeostasis
cellular response to mechanical stimulus
cellular response to iron ion
cellular response to BMP stimulus
positive regulation of DNA-dependent DNA replication
positive regulation of aldosterone secretion
ossification
multicellular organism development
cell differentiation
cell development
response to iron ion
regulation of cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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