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Proteintech
BMP7 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
12221-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BMP7 Fusion Protein Ag2902 (82-431 aa encoded by BC008584)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY RNMVVRACGC H (82-431 aa encoded by BC008584)
Target Information
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP; BMP7; Bone morphogenetic protein; osteogenic protein 1; RP11-560A15.5; unnamed protein product
Gene Aliases: OP-1; OP1
UniProt ID: (Human) P18075, (Mouse) P23359
Entrez Gene ID: (Human) 655, (Mouse) 12162
skeletal system development
osteoblast differentiation
eye development
metanephros development
ureteric bud development
mesonephros development
epithelial to mesenchymal transition
endocardial cushion formation
pericardium morphogenesis
heart development
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of striated muscle cell apoptotic process
positive regulation of epithelial to mesenchymal transition
dendrite development
neural fold elevation formation
positive regulation of bone mineralization
BMP signaling pathway
hindbrain development
response to estradiol
response to vitamin D
positive regulation of heterotypic cell-cell adhesion
response to peptide hormone
positive regulation of cell differentiation
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of cell cycle
negative regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
cardiac muscle tissue development
mesenchymal cell differentiation
neuron projection morphogenesis
positive regulation of multicellular organismal process
pharyngeal system development
positive regulation of SMAD protein import into nucleus
cardiac septum morphogenesis
mesenchyme development
chorio-allantoic fusion
heart trabecula morphogenesis
monocyte aggregation
cellular response to hypoxia
cellular response to BMP stimulus
negative regulation of glomerular mesangial cell proliferation
metanephric mesenchyme morphogenesis
nephrogenic mesenchyme morphogenesis
metanephric mesenchymal cell proliferation involved in metanephros development
positive regulation of brown fat cell differentiation
cell-cell adhesion
positive regulation of dendrite development
positive regulation of hyaluranon cable assembly
negative regulation of NIK/NF-kappaB signaling
allantois development
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of multicellular organismal development
regulation of removal of superoxide radicals
mesoderm formation
kidney development
pattern specification process
axon guidance
salivary gland morphogenesis
embryonic pattern specification
organ morphogenesis
regulation of signal transduction
embryonic limb morphogenesis
epithelial cell differentiation
tube morphogenesis
regulation of phosphorylation
odontogenesis of dentin-containing tooth
positive regulation of apoptotic process
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
cell development
camera-type eye morphogenesis
embryonic camera-type eye morphogenesis
anatomical structure formation involved in morphogenesis
branching morphogenesis of an epithelial tube
negative regulation of neurogenesis
embryonic skeletal joint morphogenesis
branching involved in salivary gland morphogenesis
negative regulation of prostatic bud formation
regulation of branching involved in prostate gland morphogenesis
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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