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Product Details
BMP8-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 160-200 on human BMP8 protein
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP-8; BMP-8A; BMP-8B; Bone morphogenetic protein; bone morphogenetic protein 8 (osteogenic protein 2); Bone morphogenetic protein 8A; Bone morphogenetic protein 8B; dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); MGC131757; OP-2; Osteogenic protein 2
Gene Aliases: Bmp-8; Bmp7r1; BMP8; BMP8A; BMP8B; OP-2; OP2; Op3
UniProt ID: (Human) Q7Z5Y6, (Human) P34820, (Mouse) P34821, (Mouse) P55105
Entrez Gene ID: (Human) 353500, (Human) 656, (Mouse) 12163, (Rat) 680931, (Mouse) 12164, (Rat) 679119
ossification
diet induced thermogenesis
positive regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of insulin secretion
cell development
cartilage development
SMAD protein signal transduction
regulation of energy homeostasis
skeletal system development
osteoblast differentiation
transforming growth factor beta receptor signaling pathway
multicellular organism development
germ cell development
spermatogenesis
cell differentiation
embryonic morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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