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Invitrogen

BMPR1A Polyclonal Antibody

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View all (14) BMPR1A antibodies

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BMPR1A Polyclonal Antibody

Product Details

PA5-18494

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (KSDSDQKKSEN) corresponding to the internal amino acids of BMPR1A (aa 36-46).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980930

Product Specific Information

This antibody is predicted to react with canine based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Target Information

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPRIA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5; unnamed protein product

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Gene Aliases: 10q23del; 1110037I22Rik; ACVRLK3; ALK-3; ALK3; AU045487; Bmpr; BMPR-1A; BMPR-IA; BMPR1A; CD292; SKR5

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UniProt ID: (Human) P36894, (Mouse) P36895

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Entrez Gene ID: (Human) 657, (Mouse) 12166

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I protein binding ATP binding kinase activity transferase activity BMP binding protein homodimerization activity SMAD binding metal ion binding BMP receptor activity RNA polymerase II transcription factor activity, sequence-specific DNA binding glycoprotein binding receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
angiogenesis osteoblast differentiation in utero embryonic development mesoderm formation somitogenesis Mullerian duct regression positive regulation of mesenchymal cell proliferation chondrocyte differentiation heart morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development atrioventricular valve development mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis endocardial cushion formation cellular iron ion homeostasis immune response transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway pattern specification process ectoderm development nervous system development endoderm development heart development dorsal/ventral axis specification anterior/posterior pattern specification dorsal/ventral pattern formation positive regulation of gene expression negative regulation of gene expression regulation of cardiac muscle cell apoptotic process neural crest cell development negative regulation of smooth muscle cell migration central nervous system neuron differentiation pituitary gland development neural plate mediolateral regionalization cell differentiation lung development positive regulation of bone mineralization BMP signaling pathway positive regulation of transforming growth factor beta2 production somatic stem cell population maintenance hindlimb morphogenesis dorsal aorta morphogenesis odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm development paraxial mesoderm structural organization lateral mesoderm development regulation of lateral mesodermal cell fate specification mesendoderm development embryonic organ development developmental growth embryonic morphogenesis stem cell differentiation epithelial cell proliferation positive regulation of epithelial cell proliferation negative regulation of neurogenesis negative regulation of muscle cell differentiation cartilage development palate development regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis neural plate pattern specification heart formation atrioventricular node cell development pharyngeal arch artery morphogenesis cellular response to growth factor stimulus cellular response to BMP stimulus positive regulation of dendrite development positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of cardiac ventricle development positive regulation of vascular smooth muscle cell proliferation fibrous ring of heart morphogenesis regulation of neural crest cell differentiation anti-Mullerian hormone signaling pathway regulation of cellular senescence regulation of endothelial cell proliferation transcription from RNA polymerase II promoter protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation phosphorylation stem cell population maintenance regulation of endothelial cell differentiation positive regulation of transcription, DNA-templated
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