Keep as concentrated solution.
Predicted reactivity: Mouse (99%), Rat (98%), Xenopus laevis (89%), Dog (99%), Pig (100%), Chicken (95%), Sheep (99%), Rhesus Monkey (100%), Bovine (98%).
Positive Control: human BMPR1A-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; BMPRIA; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
Gene Aliases: 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5
UniProt ID: (Human) P36894
Entrez Gene ID: (Human) 657
Molecular Function: serine/threonine protein kinase receptor