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Proteintech
BMPR2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
19087-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BMPR2 Fusion Protein Ag5868 (172-504 aa encoded by BC052985)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.37 mg/mL
Amount
55.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes endogenous levels of total BMPR2 protein, including 115 kDa precursor, 75 kDa mature form and 150 kDa dimer.
Immunogen sequence: YRMLTGDRK QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER MAEL (172-504 aa encoded by B C052985)
Target Information
BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP type II receptor; BMP type-2 receptor; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3
Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPRII; BRK-3; Gm20272; PPH1
UniProt ID: (Mouse) O35607
Entrez Gene ID: (Rat) 140590, (Mouse) 12168
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
ATP binding
growth factor binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
BMP binding
metal ion binding
serine/threonine protein kinase receptor
mesoderm formation
maternal placenta development
positive regulation of endothelial cell proliferation
lymphangiogenesis
blood vessel remodeling
chondrocyte development
negative regulation of systemic arterial blood pressure
transcription from RNA polymerase II promoter
protein phosphorylation
transmembrane receptor protein serine/threonine kinase signaling pathway
brain development
cellular response to starvation
anterior/posterior pattern specification
positive regulation of endothelial cell migration
positive regulation of epithelial cell migration
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of lung blood pressure
signal transduction by protein phosphorylation
proteoglycan biosynthetic process
negative regulation of cell growth
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of BMP signaling pathway
regulation of cell proliferation
positive regulation of osteoblast differentiation
negative regulation of vasoconstriction
vascular endothelial growth factor receptor signaling pathway
lung alveolus development
positive regulation of axon extension involved in axon guidance
retina development in camera-type eye
limb development
endochondral bone morphogenesis
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
positive regulation of cartilage development
retina vasculature development in camera-type eye
negative regulation of chondrocyte proliferation
negative regulation of DNA biosynthetic process
positive regulation of protein phosphorylation
endothelial cell proliferation
phosphorylation
endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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