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Proteintech

BMPR2 Polyclonal Antibody

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BMPR2 Polyclonal Antibody

Product Details

19087-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells
-

Immunoprecipitation (IP)

0.5-4.0 µg
-

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication

Not applicable (N/A)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BMPR2 Fusion Protein Ag5868 (172-504 aa encoded by BC052985)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes endogenous levels of total BMPR2 protein, including 115 kDa precursor, 75 kDa mature form and 150 kDa dimer.

Immunogen sequence: YRMLTGDRK QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER MAEL (172-504 aa encoded by B C052985)

Target Information

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BMP type II receptor; BMP type-2 receptor; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4; unnamed protein product

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Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK

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UniProt ID: (Human) Q13873, (Mouse) O35607

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Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity protein binding ATP binding kinase activity activin receptor activity, type II transferase activity growth factor binding BMP binding cadherin binding metal ion binding BMP receptor activity protein tyrosine kinase binding receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
regulation of cell growth blood vessel development osteoblast differentiation mesoderm formation maternal placenta development endothelial cell proliferation vasculature development lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure outflow tract septum morphogenesis outflow tract morphogenesis aortic valve development pulmonary valve development atrioventricular valve morphogenesis mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion development negative regulation of cell proliferation involved in heart valve morphogenesis transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell proliferation cellular response to starvation tissue development anterior/posterior pattern specification positive regulation of gene expression positive regulation of epithelial cell migration regulation of lung blood pressure cell differentiation proteoglycan biosynthetic process negative regulation of cell growth lung development positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway positive regulation of locomotion regulation of cell proliferation positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter lung alveolus development negative regulation of smooth muscle cell proliferation cardiac muscle tissue development positive regulation of axon extension involved in axon guidance stem cell differentiation negative regulation of muscle cell differentiation retina development in camera-type eye limb development endochondral bone morphogenesis positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis atrial septum morphogenesis lung vasculature development lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye pharyngeal arch artery morphogenesis cellular response to growth factor stimulus cellular response to BMP stimulus endothelial cell apoptotic process negative regulation of chondrocyte proliferation semi-lunar valve development regulation of multicellular organismal development positive regulation of endothelial cell proliferation transcription from RNA polymerase II promoter protein phosphorylation brain development positive regulation of endothelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation signal transduction by protein phosphorylation positive regulation of BMP signaling pathway vascular endothelial growth factor receptor signaling pathway negative regulation of DNA biosynthetic process positive regulation of protein phosphorylation phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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