In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) BMPR-IA, recombinant mouse (rm) BMPR-IA, rhBMPR-IB, and rmBMPR-IB is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
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Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II; BMPR3; BMR2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); PPH1; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Gene Aliases: BMPR-II; BMPR2; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK
UniProt ID: (Human) Q16569
Entrez Gene ID: (Human) 659