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Invitrogen
CD44var (v7-v8) Monoclonal Antibody (VFF-17), eBioscience™
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FIGURE: 1 / 1
CD44var (v7-v8) Antibody (BMS118) in IHC
International journal of cancer 2002 -
3 Staining of xenograft breast tumor sections. Tumors were obtained from SCID mice bearing human tumors derived from the breast carcinoma cell line MDA435. Sections were stained for HA, CD44s and CD44 variant v7-8. Tumors were harvested on Day 12 after the start of hyaluronidase treatment. Treatment consisted of 4 i.v. injections of 75 rTRU of hyaluronidase on Days 0, 2, 4 and 6. Histolocalization of HA ... View More
Product Details
BMS118
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
VFF-17
Immunogen
Rec. Human CD44var (v7-v8)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2-7.4
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: Specifically recognizes an epitope encoded by exons v7-v8 on the variant portion of human CD44.
Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.
Applications Tested: Flow Cytometry, Immunohistochemistry (Frozen), Western Blotting.
Purity: >95%.
Target Information
CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AL133330.1; CD44; CD44 antigen; CD44 molecule (Indian blood group); CD44 splice variant; CD44 var; CD44 variant; CD44R1; CD44v7; CD44v7-8; CD44v7-v8; CD44v8; CDw44; CDw44 antigen precursor; cell surface glycoprotein CD44; cell-cell and cell-matrix adhesion interaction glycoprotein isoform; cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; H-CAM v7; H-CAM v8; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; Hermes antigen gp90 homing receptor precursor; homing cell adhesion molecule; homing function and Indian blood group system; homing receptor; HUTCH-I; HUTCHI; hyaluronan-binding protein; Hyaluronate receptor; In(Lu) related-p80; Indian blood group antigen; PGP I; PGP-1; PGP-I; phagocyte glycoprotein 1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; soluble CD44; unnamed protein product
Gene Aliases: CD44; CDW44; CSPG8; ECM-III; ECMR-III; H-CAM; HCELL; Hermes-1; HUTCH-1; HUTCH-I; LHR; MC56; MDU2; MDU3; MIC4; Pgp1
UniProt ID: (Human) P16070
Entrez Gene ID: (Human) 960
inflammatory response
cell adhesion
cell-matrix adhesion
anatomical structure morphogenesis
cell migration
cytokine-mediated signaling pathway
hyaluronan catabolic process
positive regulation of heterotypic cell-cell adhesion
T cell activation
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
wound healing, spreading of cells
cellular response to fibroblast growth factor stimulus
system development
cartilage development
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
cell-cell adhesion
positive regulation of monocyte aggregation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of lamellipodium morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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