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QED Bioscience

BNIP3 Polyclonal Antibody

View all (16) BNIP3 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

2290-100UG

Applications Tested Dilution Publications

Western Blot (WB)

 1 µg/mL -

Immunocytochemistry (ICC/IF)

 Assay-dependent -
Product Specifications

Species Reactivity

 Human, Mouse

Host/Isotype

 Rabbit

Class

 Polyclonal

Type

 Antibody

Immunogen

Synthetic peptide corresponding to amino acids at the C-terminus of human BNIP3.
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Antigen affinity chromatography

Storage buffer

 PBS, pH 7.4, with 50% glycerol

Contains

 0.09% sodium azide

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

Target Information

NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B interacting protein 1, NIP3

Gene Aliases: BNIP3; NIP3

UniProt ID: (Human) Q12983, (Mouse) O55003

Entrez Gene ID: (Human) 664, (Mouse) 12176

Function(s)
response to hypoxia apoptotic process cell death granzyme-mediated apoptotic signaling pathway negative regulation of mitochondrial fusion regulation of mitochondrion organization mitochondrial protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death positive regulation of protein complex disassembly mitochondrial fragmentation involved in apoptotic process negative regulation of membrane potential regulation of mitochondrial membrane permeability autophagic cell death brown fat cell differentiation neuron apoptotic process defense response to virus cellular response to hydrogen peroxide cellular response to cobalt ion cellular response to hypoxia reactive oxygen species metabolic process positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway mitochondrial outer membrane permeabilization toxin transport regulation of aerobic respiration intrinsic apoptotic signaling pathway in response to hypoxia negative regulation of reactive oxygen species metabolic process mitophagy positive regulation of autophagy positive regulation of cardiac muscle cell apoptotic process positive regulation of macroautophagy response to hyperoxia negative regulation of cell death cellular response to mechanical stimulus
Process(es)
protein binding identical protein binding protein homodimerization activity protein heterodimerization activity GTPase binding
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