Invitrogen

BNIP3 Polyclonal Antibody

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BNIP3 Polyclonal Antibody

Product Details

PA5-96388

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.27 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808190

Product Specific Information

Immunogen sequence: AFPPPAAEAH PAARRGLRSP QLPSGAMSQN GAPGMQEESL QGSWVELHFS NNGNGGSVPA SVSIYNGDME KILLDAQHES G

Positive Samples: A375, Mouse heart; Cellular Location: Mitochondrion, Mitochondrion outer membrane, Single-pass membrane protein

Target Information

NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B 19 kDa-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B interacting protein 1, NIP3

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Gene Aliases: BNIP3; NIP3

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UniProt ID: (Human) Q12983, (Mouse) O55003

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Entrez Gene ID: (Human) 664, (Rat) 84480, (Mouse) 12176

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Function(s)
protein binding identical protein binding protein homodimerization activity protein heterodimerization activity GTPase binding
Process(es)
response to hypoxia apoptotic process cell death granzyme-mediated apoptotic signaling pathway negative regulation of mitochondrial fusion mitochondrial protein catabolic process positive regulation of apoptotic process positive regulation of programmed cell death positive regulation of protein complex disassembly mitochondrial fragmentation involved in apoptotic process negative regulation of membrane potential regulation of mitochondrial membrane permeability autophagic cell death brown fat cell differentiation neuron apoptotic process defense response to virus response to hyperoxia cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to cobalt ion cellular response to hypoxia reactive oxygen species metabolic process positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway mitochondrial outer membrane permeabilization toxin transport intrinsic apoptotic signaling pathway in response to hypoxia regulation of mitochondrion organization negative regulation of apoptotic process regulation of aerobic respiration negative regulation of reactive oxygen species metabolic process mitophagy positive regulation of autophagy positive regulation of cardiac muscle cell apoptotic process positive regulation of macroautophagy negative regulation of cell death
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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