This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
In Western blot, an upper band is detected at ~40kDa, which represents the monomer of Bnip3L. A suggested positive control is K562 cell lysate.
PA5-19958 can be used with blocking peptide PEP-0083.
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3alpha, and Nix (for Nip3-like protein X). Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
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Protein Aliases: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19kDa interacting protein 3 like; BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNIP3a, NIX; NIP3-like protein X; NIP3L
Gene Aliases: BNIP3A; BNIP3H; BNIP3L; NIX
UniProt ID: (Human) O60238
Entrez Gene ID: (Human) 665