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Proteintech
BNP Polyclonal Antibody
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Product Details
13299-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BNP Fusion Protein Ag4039 (1-134 aa encoded by BC025785)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDPQTAPSR ALLLLLFLHL AFLGGRSHPL GSPGSASDLE TSGLQEQRNH LQGKLSELQV EQTSLEPLQE SPRPTGVWKS REVATEGIRG HRKMVLYTLR APRSPKMVQG SGCFGRKMDR ISSSSGLGCK VLRRH (1-134 aa encoded by BC025785)
Target Information
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BNP-32; Brain natriuretic factor prohormone; brain type natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; Natriuretic peptides B; natriuretic protein; NPPB; preproBNP; proBNP
Gene Aliases: BNP; Iso-ANP; NPPB
UniProt ID: (Human) P16860
Entrez Gene ID: (Human) 4879
system process
negative regulation of systemic arterial blood pressure
cardiac conduction system development
cGMP biosynthetic process
protein folding
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
neuropeptide signaling pathway
body fluid secretion
regulation of blood pressure
negative regulation of angiogenesis
cGMP-mediated signaling
negative regulation of cell growth
killing of cells of other organism
positive regulation of urine volume
positive regulation of renal sodium excretion
vasodilation
regulation of vascular permeability
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of blood vessel diameter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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