Immunogen sequence: MDPQTAPSRA LLLLLFLHLA FLGGRSHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PRSPKMVQGS GCFGRKMDRI SSSSGLGCKV LRRH; Positive Samples: Rat heart
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
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Protein Aliases: 5 kDa cardiac natriuretic peptide; BNP; BNP-34; Brain natriuretic factor; Brain natriuretic peptide; Brain natriuretic peptide 45; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; Natriuretic peptides B; type-B natriuretic factor
Gene Aliases: AA408272; BNF; BNP; Nppb