Positive control: Recombinant BNP protein
Cellular location: Cytoplasmic, secreted.
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BNP; BNP(1-28); BNP(1-29); BNP(1-30); BNP(1-32); BNP(2-31); BNP(3-29); BNP(3-30); BNP(3-32); BNP(4-27); BNP(4-29); BNP(4-30); BNP(4-31); BNP(4-32); BNP(5-29); BNP(5-31); BNP(5-32); Brain natriuretic factor prohormone; Brain natriuretic peptide; Brain natriuretic peptide 29; Brain natriuretic peptide 32; brain type natriuretic peptide; des-SerPro-BNP; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; Natriuretic peptides B; natriuretic protein; NT-pro-BNP; NT-proBNP; NT-proBNP(1-76); preproBNP; proBNP(3-108); proBNP(79-108)
Gene Aliases: BNP; NPPB
UniProt ID: (Human) P16860
Entrez Gene ID: (Human) 4879