Sequence of this protein is as follows: METESGPQTS NQMQTDSLSP SPNPVSPVPL NNPTSAPRYG TVIPNRIFVG GIDFKTNESD LRKFFSQYGS VKEVKIVNDR AGVSKGYGFV TFETQEDAQK ILQEAEKLNY KDKKLNIGPA IRKQQVGIPR SSIMPAAGTM YLTTSTGYPY TYHNGVAYFH TPEVTSVPPP WPSRSVCSSP VMVAQPIYQQ PAYHYQATTQ YLPGQWQWSV PQPSASSAPF LYLQPSEVIY QPVEIAQDGG CVPPPLSLME TSVPEPYSDH GVQATYHQVY APSAITMPAP VMQPEPIKTV WSIHY
This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Protein Aliases: bol, boule-like; boule-like RNA binding protein; boule-like RNA-binding protein; Protein boule-like
Gene Aliases: 4930554P13Rik; 4930597B14Rik; BOLL; BOULE