Immunogen sequence: MPRNLLYSL LSSHLSPHFS TSVTSAKVAV NGVQLHYQQT GEGDHAVLLL PGMLGSGETD FGPQLKNLNK KLFTVVAWDP RGYGHSRPPD RDFPADFFER DAKDAVDLMK ALKFKKVSLL GWSDGGITAL IAAAKYPSYI HKMVIWGANA YVTDEDSMIY EGIRDVSKWS ERTRKPLEAL YGWSLTLSPG WNAMA (1-194 aa encoded by BC037778)
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen); Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA; Poly(ADP-ribose) glycohydrolase; VACVase; Valacyclovir hydrolase; valacyclovirase
Gene Aliases: 2010012D11Rik; 5730533B08Rik; AI115341; BPH-RP; BPHL; MCNAA; PARG; VACVASE