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BRCA1 Polyclonal Antibody

View all (94) BRCA1 antibodies

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BRCA1 Polyclonal Antibody

Product Details

HA500015

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein within human BRCA1 aa 1-200.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.4, with 0.2% BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brca 1; brca-1; BRCA1/BRCA2-containing complex, subunit 1; breast and ovarian cancer susceptibility protein 1; breast cancer 1 early onset; breast cancer 1, early onset; breast cancer associated 1; Breast cancer type 1 susceptibility protein; Breast cancer type 1 susceptibility protein homolog; breast cancer type 1 susceptibility protein isoform p.23; breast cancer type 1 susceptibility protein, isoform p.10; breast cancer type 1 susceptibility protein, isoform p.11; breast cancer type 1 susceptibility protein, isoform p.12; breast cancer type 1 susceptibility protein, isoform p.13; breast cancer type 1 susceptibility protein, isoform p.14; breast cancer type 1 susceptibility protein, isoform p.15; breast cancer type 1 susceptibility protein, isoform p.16; breast cancer type 1 susceptibility protein, isoform p.17; breast cancer type 1 susceptibility protein, isoform p.18; breast cancer type 1 susceptibility protein, isoform p.19; breast cancer type 1 susceptibility protein, isoform p.20; breast cancer type 1 susceptibility protein, isoform p.21; breast cancer type 1 susceptibility protein, isoform p.22; breast cancer type 1 susceptibility protein, isoform p.24; breast cancer type 1 susceptibility protein, isoform p.25; breast cancer type 1 susceptibility protein, isoform p.26; breast cancer type 1 susceptibility protein, isoform p.27; breast cancer type 1 susceptibility protein, isoform p.28; breast cancer type 1 susceptibility protein, isoform p.29; breast cancer type 1 susceptibility protein, isoform p.30; breast cancer type 1 susceptibility protein, isoform p.31; breast cancer type 1 susceptibility protein, isoform p.32; breast cancer type 1 susceptibility protein, isoform p.33; breast cancer type 1 susceptibility protein, isoform p.34; breast cancer type 1 susceptibility protein, isoform p.35; breast cancer type 1 susceptibility protein, isoform p.36; breast cancer type 1 susceptibility protein, isoform p.37; breast cancer type 1 susceptibility protein, isoform p.38; breast cancer type 1 susceptibility protein, isoform p.39; breast cancer type 1 susceptibility protein, isoform p.40; breast cancer type 1 susceptibility protein, isoform p.41; breast cancer type 1 susceptibility protein, isoform p.42; breast cancer type 1 susceptibility protein, isoform p.6; breast cancer type 1 susceptibility protein, isoform p.7; breast cancer type 1 susceptibility protein, isoform p.8; breast cancer type 1 susceptibility protein, isoform p.9; BROVCA12; Delta772-3095; early onset breast cancer 1; Fanconi anemia, complementation group S; influences susceptibility to breast and ovarian cancer; OTTHUMP00000212147; OTTHUMP00000212148; OTTHUMP00000212149; OTTHUMP00000212150; OTTHUMP00000212151; OTTHUMP00000212155; protein phosphatase 1, regulatory subunit 53; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1; unnamed protein product

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Gene Aliases: BRCA1; BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53

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UniProt ID: (Human) P38398, (Mouse) P48754, (Rat) O54952

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Entrez Gene ID: (Human) 672, (Mouse) 12189, (Rat) 497672

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Function(s)
transcription regulatory region sequence-specific DNA binding p53 binding DNA binding damaged DNA binding transcription coactivator activity RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding tubulin binding transferase activity enzyme binding ubiquitin protein ligase binding identical protein binding metal ion binding ubiquitin protein ligase activity ubiquitinated histone binding RNA polymerase binding histone H2AK127 ubiquitin ligase activity histone H2AK129 ubiquitin ligase activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity transcription regulatory region DNA binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase protein modifying enzyme
Process(es)
double-strand break repair via homologous recombination DNA repair regulation of DNA repair postreplication repair double-strand break repair DNA recombination chromatin remodeling regulation of transcription from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process cellular response to DNA damage stimulus chromosome segregation mitotic G2 DNA damage checkpoint centrosome cycle dosage compensation intrinsic apoptotic signaling pathway in response to DNA damage response to ionizing radiation positive regulation of vascular endothelial growth factor production positive regulation of gene expression protein ubiquitination negative regulation of cell growth negative regulation of intracellular estrogen receptor signaling pathway reciprocal DNA recombination chordate embryonic development hypermethylation of CpG island mitotic G2/M transition checkpoint negative regulation of fatty acid biosynthetic process positive regulation of DNA repair positive regulation of angiogenesis negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of centriole replication regulation of cell cycle protein autoubiquitination random inactivation of X chromosome cellular response to tumor necrosis factor cellular response to ionizing radiation cellular response to indole-3-methanol protein K6-linked ubiquitination DNA strand resection involved in replication fork processing negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of DNA damage checkpoint negative regulation of reactive oxygen species metabolic process DNA replication regulation of gene expression by genetic imprinting cell cycle dosage compensation by inactivation of X chromosome chromosome breakage positive regulation of protein ubiquitination G2 DNA damage checkpoint positive regulation of histone acetylation negative regulation of histone acetylation regulation of cell proliferation response to estrogen regulation of DNA methylation centrosome duplication positive regulation of histone H3-K4 methylation negative regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation positive regulation of histone H3-K9 methylation positive regulation of histone H4-K20 methylation positive regulation of cell cycle arrest positive regulation of histone H3-K9 acetylation positive regulation of histone H4-K16 acetylation brain development response to nutrient response to organic substance response to estradiol response to lipid regulation of cell motility
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