FIGURE: 1 / 13
Immunogen sequence: LESDAFLVC LNHALSTEKE EVMGLCIGEL NDDTRSDSKF AYTGTEMRTV AEKVDAVRIV HIHSVIILRR SDKRKDRVEI SPEQLSAAST EAERLAELTG RPMRVVGWYH SHPHITVWPS HVDVRTQAMY QMMDQGFVGL IFSCFIEDKN TKTGRVLYTC FQSIQAQKSS ESLHGPRDFW SSSQHISIEG QKEEERYERI EIPIHIVPHV TIGKVCLESA VELPKILCQE EQDAYRRIHS LTHLDSVTKI HNGSVFTKNL CSQMSAVSGP LLQWLEDRLE QNQQHLQELQ QEKEELMQEL SSLE (14-316 aa encoded by BC002999)
Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.
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Protein Aliases: 6.1A protein; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36; Lys-63-specific deubiquitinase BRCC36; RP11-143H17.2
Gene Aliases: BRCC3; BRCC36; C6.1A; CXorf53
Molecular Function: translation initiation factor