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Invitrogen
BRD2 Recombinant Rabbit Monoclonal Antibody (R2A5)
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FIGURE: 1 / 4
BRD2 Antibody (MA572019) in ICC/IF
Immunocytochemistry analysis of BRD2 in HeLa cells. Permeabilized with Trinton X-100 at room temp for 20 min. Samples were incubated with BRD2 Recombinant Monoclonal (Product # MA572019 using a dilution at 1:100, for 90 min at 37°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green) at 37°C for 90 min, DAPI was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
Product Details
MA572019
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R2A5
Immunogen
Recombinant protein within human BRD2 aa 1-200. 1-50/801.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Protein A
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21. 3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRD2 intronic transcript 1; Bromodomain-containing protein 2; DADB-17J1.3; DKFZp686N0336; female sterile homeotic-related gene 1; FLJ31942; FSH; KIAA9001; O27.1.1; putative; really interesting new gene 3 protein; RING3 protein
Gene Aliases: BRD2; BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; KIAA9001; NAT; O27.1.1; RING3; RNF3
UniProt ID: (Human) P25440
Entrez Gene ID: (Human) 6046
neural tube closure
chromatin organization
nucleosome assembly
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade
spermatogenesis
regulation of gene expression
protein localization to chromatin
T-helper 17 cell lineage commitment
chromatin looping
positive regulation of T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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