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Invitrogen
BRG1 Polyclonal Antibody
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Product Details
PA5-149057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human Brg1, Gln673-Asn774
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SMARCA4; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1; unnamed protein product
Gene Aliases: BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; OTSC12; RTPS2; SMARCA4; SNF2; SNF2-beta; SNF2B; SNF2L4; SNF2LB; SWI2
UniProt ID: (Human) P51532
Entrez Gene ID: (Human) 6597
RNA polymerase I CORE element sequence-specific DNA binding
transcription cofactor binding
p53 binding
DNA binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
RNA binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
hydrolase activity
ATPase activity
Tat protein binding
nucleosomal DNA binding
histone binding
identical protein binding
androgen receptor binding
DNA polymerase binding
ATP-dependent chromatin remodeler activity
nucleosome array spacer activity
negative regulation of transcription from RNA polymerase II promoter
RNA polymerase I preinitiation complex assembly
neural retina development
chromatin organization
nucleosome disassembly
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of cell proliferation
regulation of mitotic metaphase/anaphase transition
positive regulation of Wnt signaling pathway
negative regulation of cell growth
heterochromatin assembly
positive regulation by host of viral transcription
positive regulation of T cell differentiation
negative regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of androgen receptor signaling pathway
regulation of G0 to G1 transition
positive regulation of cold-induced thermogenesis
positive regulation of signal transduction by p53 class mediator
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
positive regulation of stem cell population maintenance
positive regulation of glucose mediated signaling pathway
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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