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Proteintech
BRIP1 Polyclonal Antibody
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Product Details
24436-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BRIP1 Fusion Protein Ag19907 (1-342 aa encoded by BC101472)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSSMWSEYT IGGVKIYFPY KAYPSQLAMM NSILRGLNSK QHCLLESPTG SGKSLALLCS ALAWQQSLSG KPADEGVSEK AEVQLSCCCA CHSKDFTNND MNQGTSRHFN YPSTPPSERN GTSSTCQDSP EKTTLAAKLS AKKQASIYRD ENDDFQVEKK RIRPLETTQQ IRKRHCFGTE VHNLDAKVDS GKTVKLNSPL EKINSFSPQK PPGHCSRCCC STKQGNSQES SNTIKKDHTG KSKIPKIYFG TRTHKQIAQI TRELRRTAYS GVPMTILSSR DHTCVHPEVV GNFNRNEKCM ELLDGKNGKS CYFYHGVHKI SDQHTLQTFQ GMCKAWDIEE LVS (1-342 aa encoded by BC101472)
Target Information
BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) is a gene situated on chromosome 17q22, covering 19 exons within its 184-kb coding region to encode a protein containing 1249 amino acids. BRIP1 is integral to the DNA repair processes, specifically through its interaction with the BRCA1 gene, and is involved in the Fanconi anemia complementation group J (FANC J). Mutations in BRIP1 have been identified, playing a role in cancer predisposition with a notable eightfold increased risk for ovarian cancer and associations with cervical cancer risk through its single nucleotide polymorphisms (SNPs). Amplifications and other mutations of BRIP1 are prevalent in a variety of cancers, and its expression involves significant correlations with copy number variations (CNV) and DNA methylation across numerous tumor types. BRIP1's expression is upregulated in certain contexts, which can contribute to cancer progression, as evidenced in the Omani population with breast cancer. These interactions validate its association with DNA damage repair, cell cycle, and metabolism across multiple cancer types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-dependent RNA helicase BRIP1; BACH 1; BACH1 BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1/BRCA2-associated helicase 1; BRIP 1; DNA 5'-3' helicase FANCJ; FANCJ protein; Fanconi anemia group J protein; Fanconi anemia group J protein homolog; FLJ90232; MGC126521; MGC126523
Gene Aliases: 3110009N10Rik; 8030460J03Rik; BACH1; BRIP1; FACJ; FANCJ; OF
UniProt ID: (Human) Q9BX63, (Mouse) Q5SXJ3
Entrez Gene ID: (Human) 83990, (Mouse) 237911
DNA binding
ATP-dependent DNA helicase activity
protein binding
ATP binding
metal ion binding
4 iron, 4 sulfur cluster binding
nucleotide binding
nucleic acid binding
helicase activity
ATP-dependent helicase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
iron-sulfur cluster binding
DNA helicase
DNA damage checkpoint
DNA synthesis involved in DNA repair
strand displacement
DNA replication
double-strand break repair
regulation of transcription from RNA polymerase II promoter
negative regulation of cell proliferation
DNA duplex unwinding
cellular response to vitamin
regulation of signal transduction by p53 class mediator
nucleobase-containing compound metabolic process
DNA repair
cellular response to DNA damage stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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