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Product Details
PA5-120312
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 90-210 of human BRMS1 (NP_056214.1).
Conjugate
Unconjugated
Form
Liquid
Concentration
2.91 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2913884
Product Specific Information
Positive test controls include: Mouse kidney, Mouse testis. The target is usually found in the following locations: Cytoplasm, Nucleus.
Immunogen sequence: LEEVGAERAP EYTEPLGGLQ RSLKIRIQVA GIYKGFCLDV IRNKYECELQ GAKQHLESEK LLLYDTLQGE LQERIQRLEE DRQSLDLSSE WWDDKLHARG SSRSWDSLPP SKRKKAPLVS G
Target Information
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: breast cancer metastasis suppressor 1; Breast cancer metastasis-suppressor 1; Breast cancer metastasis-suppressor 1 homolog; BRMS 1
Gene Aliases: AV003220; AW554636; BRMS1
UniProt ID: (Human) Q9HCU9, (Rat) Q5M7T3, (Mouse) Q99N20
Entrez Gene ID: (Human) 25855, (Rat) 293668, (Mouse) 107392
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
apoptotic process
histone deacetylation
negative regulation of NF-kappaB transcription factor activity
negative regulation of transcription, DNA-templated
positive regulation of protein deacetylation
positive regulation of anoikis
regulation of transcription, DNA-templated
cellular process
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