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BRN3B Polyclonal Antibody
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Product Details
BS-6985R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BRN3B/POU4F2, amino acids 301-400.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons. POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3.2; Brn-3b; Brn3b POU domain transcription factor; POU domain protein; POU domain, class 4, transcription factor 2; POU domain, class 4, transcription factor, related sequence 1; POU4F2; unnamed protein product
Gene Aliases: Brn-3.2; Brn-3b; BRN3.2; BRN3B; mBrn3-3R; Pou4f-rs1; POU4F2
UniProt ID: (Human) Q12837, (Rat) G3V7L5, (Mouse) Q63934
Entrez Gene ID: (Human) 5458, (Rat) 171355, (Mouse) 18997
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
promoter-specific chromatin binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
axonogenesis
axon guidance
heart development
sensory perception of sound
cell differentiation
neuron differentiation
intracellular estrogen receptor signaling pathway
retinal ganglion cell axon guidance
cellular response to insulin stimulus
positive regulation of programmed cell death
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of osteoclast differentiation
positive regulation of axon extension
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
axon extension
neuromuscular process controlling balance
regulation of sequence-specific DNA binding transcription factor activity
retina development in camera-type eye
cellular response to cytokine stimulus
cellular response to estradiol stimulus
intrinsic apoptotic signaling pathway by p53 class mediator
regulation of retinal ganglion cell axon guidance
negative regulation of amacrine cell differentiation
negative regulation of adipose tissue development
dorsal root ganglion development
positive regulation of transcription regulatory region DNA binding
transcription, DNA-templated
spermatogenesis
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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