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Bioss
BRN3B Polyclonal Antibody
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Product Details
BS-6985R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BRN3B/POU4F2, amino acids 301-400.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons. POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3.2; Brn3b POU domain transcription factor; POU domain class 4 transcription factor 2; POU domain protein; POU domain, class 4, transcription factor 2; POU domain, class 4, transcription factor, related sequence 1
Gene Aliases: Brn-3.2; Brn-3b; BRN3.2; BRN3B; mBrn3-3R; Pou4f-rs1; POU4F2
UniProt ID: (Human) Q12837, (Rat) G3V7L5, (Mouse) Q63934
Entrez Gene ID: (Human) 5458, (Rat) 171355, (Mouse) 18997
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
molecular_function
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
spermatogenesis
axon guidance
sensory perception of sound
neuron differentiation
intracellular estrogen receptor signaling pathway
retinal ganglion cell axon guidance
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
axon extension
neuromuscular process controlling balance
retina development in camera-type eye
regulation of signal transduction by p53 class mediator
transcription, DNA-templated
axonogenesis
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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