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BRSK1 Polyclonal Antibody
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Product Details
BS-7905R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BRSK1, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BRSK1 (SAD1) is a serine/threonine kinase, and is a UV-induced DNA damage checkpoint kinase. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BR serine/threonine-protein kinase 1; Brain-selective kinase 1; Brain-specific serine/threonine-protein kinase 1; protein kinase SAD1A; SAD1 homolog; SAD1 kinase; SAD1A; serine/threonine kinase SAD-B; serine/threonine kinase SADB; Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1; unnamed protein product
Gene Aliases: BRSK1; Gm1100; hSAD1; KIAA1811; RGD1563268; SAD-B; SAD1; SADB
UniProt ID: (Human) Q8TDC3, (Rat) B2DD29, (Mouse) Q5RJI5
Entrez Gene ID: (Human) 84446, (Rat) 499073, (Mouse) 381979
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
ATP binding
kinase activity
transferase activity
protein kinase binding
gamma-tubulin binding
metal ion binding
tau protein binding
tau-protein kinase activity
protein serine kinase activity
protein binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G2/M transition of mitotic cell cycle
protein phosphorylation
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
neurotransmitter secretion
nervous system development
axonogenesis
associative learning
response to UV
response to ionizing radiation
regulation of synaptic vesicle priming
regulation of neuron projection development
peptidyl-serine phosphorylation
central nervous system neuron differentiation
establishment of cell polarity
neuron differentiation
regulation of synaptic plasticity
neuron projection morphogenesis
regulation of axonogenesis
centrosome duplication
microtubule cytoskeleton organization involved in establishment of planar polarity
synaptic vesicle cycle
regulation of synaptic vesicle clustering
protein autophosphorylation
cell cycle
phosphorylation
G2 DNA damage checkpoint
intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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