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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||5 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is human small intestine tissue.
PA5-34412 can be used with blocking peptide PEP-1454.
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
APOLLON; Baculoviral IAP repeat containing 6; baculoviral IAP repeat-containing 6; BIR repeat-containing ubiquitin-conjugating enzyme; BIRC6; BRUCE; ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
APOLLON; BIRC6; BRUCE; KIAA1289