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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
WDR11 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bromodomain and WD repeat-containing protein 2; sensitization to ricin complex subunit 1; WD repeat domain 15; WD repeat-containing protein 11; WD repeat-containing protein 15
Gene Aliases: BRWD2; DR11; HH14; KIAA1351; SRI1; WDR11; WDR15
UniProt ID: (Human) Q9BZH6
Entrez Gene ID: (Human) 55717
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