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Proteintech
BSEP Polyclonal Antibody
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Product Details
18990-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
260 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; Bile salt export pump; progressive familial intrahepatic cholestasis 2; Sister of P-glycoprotein; sister p-glycoprotein
Gene Aliases: ABC16; ABCB11; BRIC2; BSEP; Lith1; PFIC-2; PFIC2; PGY4; SPGP
UniProt ID: (Human) O95342, (Mouse) Q9QY30
Entrez Gene ID: (Human) 8647, (Mouse) 27413
transporter activity
ATP binding
sodium-exporting ATPase activity, phosphorylative mechanism
canalicular bile acid transmembrane transporter activity
bile acid-exporting ATPase activity
nucleotide binding
drug transmembrane transporter activity
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
ATP-binding cassette (ABC) transporter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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