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Survivin Monoclonal Antibody (Mix-mA)

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Survivin Monoclonal Antibody (Mix-mA)

Product Details

BSM-33195M

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

Mix-mA

Immunogen

Recombinant human Survivin
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.03% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin's gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: anti-apoptosis protein; IAP; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; Baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; IAP; SVV; unnamed protein product

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Gene Aliases: AP14; API4; BIRC5; EPR-1; IAP4

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UniProt ID: (Human) O15392, (Rat) Q9JHY7

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Entrez Gene ID: (Human) 332, (Rat) 64041

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Function(s)
cysteine-type endopeptidase inhibitor activity protein binding microtubule binding zinc ion binding tubulin binding enzyme binding peptidase inhibitor activity small GTPase binding identical protein binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process metal ion binding protein heterodimerization activity cobalt ion binding chaperone binding molecular_function ubiquitin-protein transferase activity Ran GTPase binding cofactor binding
Process(es)
G2/M transition of mitotic cell cycle microtubule cytoskeleton organization transcription, DNA-templated protein phosphorylation chromosome segregation regulation of mitotic cell cycle regulation of signal transduction protein ubiquitination protein complex localization positive regulation of exit from mitosis cellular response to stem cell factor stimulus response to drug negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone negative regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of mitotic cell cycle cell division establishment of chromosome localization response to glucocorticoid regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation cellular response to ethanol mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process mitotic cell cycle mitotic cytokinesis apoptotic process mitotic spindle organization mitotic spindle assembly checkpoint sensory perception of sound positive regulation of cell proliferation mitotic spindle midzone assembly positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of mitotic sister chromatid separation positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of mitotic cytokinesis
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