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Invitrogen
BST-1 Polyclonal Antibody
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FIGURE: 1 / 4
BST-1 Antibody (PA5-106595) in ICC/IF
Immunocytochemistry analysis of BST-1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with BST-1 polyclonal antibody (Product # PA5-106595) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-106595
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BST1(Accession Q10588), corresponding to amino acid residues L78-P128.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total BST1.
Target Information
CD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST1), is a pleiotropic ectoenzyme and glycosylphosphatidylinositol-anchored molecule that functions both as an enzyme and a receptor. Similar to CD38, CD157 is involved in the metabolism of NAD+, which may play a role in regulating intracellular Ca2+ levels. As an enzyme, CD157 is also referred to as ADP-ribosyl cyclase 2 and DAMP-1, and it facilitates pre-B cell growth. As a receptor, CD157 is thought to initiate a signal transduction cascade upon binding to its putative ligand, leading to the phosphorylation of cytoplasmic proteins, including focal adhesion kinase (FAK). While the mechanism and functional significance of CD157-initiated signal transduction are not fully characterized, its role in cellular signaling is evident. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis, suggesting a link to polyclonal B cell abnormalities observed in the disease. This overexpression in the stromal cell population may contribute to the pathophysiology of rheumatoid arthritis, highlighting the importance of CD157/BST1 in both normal immune function and disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Antigen BP3; Bone marrow stromal antigen 1; Bone marrow stromal cell antigen 1; BP-3 alloantigen; BST-1; cADPR hydrolase 2; CD157; CD157 antigen; Cyclic ADP-ribose hydrolase 2; Leukocyte antigen 65; Ly-65; NAD(+) nucleosidase; NAD+ nucleosidase; unnamed protein product
Gene Aliases: 114/A10; A530073F09; BP-3; Bp3; BST1; Bsta1; cADPR2; CD157; Ly65
UniProt ID: (Human) Q10588, (Rat) Q63072, (Mouse) Q64277
Entrez Gene ID: (Human) 683, (Rat) 81506, (Mouse) 12182
regulation of cell-matrix adhesion
regulation of cellular extravasation
humoral immune response
signal transduction
positive regulation of cell proliferation
positive regulation of B cell proliferation
regulation of actin cytoskeleton organization
regulation of inflammatory response
regulation of calcium-mediated signaling
regulation of neutrophil chemotaxis
regulation of superoxide metabolic process
regulation of integrin-mediated signaling pathway
biological_process
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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