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Invitrogen
BST-2 Recombinant Rabbit Monoclonal Antibody (4L6O2)
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FIGURE: 1 / 4
BST-2 Antibody (MA5-51496) in ICC/IF
Immunocytochemistry (confocal imaging) analysis of BST-2 in HeLa cells. Samples were incubated with BST-2 Recombinant monoclonal antibody (Product # MA5-51496) using a dilution of 1:200 followed by ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) at a dilution of 1:500 (Green). The cells were counterstained with alpha-Tubulin Mouse mAb (Product # MA5-38221, dilution 1:400). DAPI was used for nuclear staining (Blue). Objective: 100x.
Product Details
MA5-51496
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4L6O2
Immunogen
Recombinant protein of human BST2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antiviral factor tetherin; Bone marrow stromal antigen 2; BST-2; CD317; HM1.24 antigen; NPC-A-7; PDCA-1; Tetherin; unnamed protein product
Gene Aliases: BST2; CD317; HM1.24; TETHERIN
UniProt ID: (Human) Q10589
Entrez Gene ID: (Human) 684
immune system process
negative regulation of plasmacytoid dendritic cell cytokine production
response to virus
negative regulation of cell growth
negative regulation of cell migration
regulation of actin cytoskeleton organization
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of viral genome replication
innate immune response
defense response to virus
positive regulation of leukocyte proliferation
negative regulation of intracellular transport of viral material
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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