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Fabgennix
BST2 Polyclonal Antibody, FITC
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Product Details
BST2-11-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mid-Region Epitope Synthetic peptide taken within amino acid region 50-100 on human Bonemarrow stromal antigen 2 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antiviral factor tetherin; Bone marrow stromal antigen 2; BST-2; CD317; DAMP-1 protein homolog; HM1.24 antigen; NPC-A-7; PDCA-1; Protein DAMP-1; Tetherin; unnamed protein product
Gene Aliases: 2310015I10Rik; Bst-2; BST2; C87040; CD317; DAMP-1; Damp1; GREG; HM1.24; TETHERIN
UniProt ID: (Human) Q10589, (Mouse) Q8R2Q8, (Rat) Q811A2
Entrez Gene ID: (Human) 684, (Mouse) 69550, (Rat) 378947
immune system process
response to virus
regulation of actin cytoskeleton organization
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
innate immune response
defense response to virus
negative regulation of intracellular transport of viral material
negative regulation of plasmacytoid dendritic cell cytokine production
negative regulation of cell growth
negative regulation of cell migration
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of leukocyte proliferation
signal transduction
negative regulation of endopeptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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