BTNL2 (butyrophilin-like protein 2), also known as BTL-II, is a 455 amino acid single-pass type II membrane protein that acts as a negative regulator of T cell proliferation. Expressed in thymus, brain, kidney, heart, liver, small intestine, testis, ovary, pancreas and leukocytes, BTNL2 exists as at least six alternatively spliced isoforms, which are encoded by a gene located on human chromosome 6. Expression of BTNL2 isoform 3 is associated with susceptibility to sarcoidosis type 2 (SS2), an immune disorder that causes chronic inflammatory granulomatous lesions.
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Protein Aliases: BTL-II; butyrophilin-like 2 (MHC class II associated); Butyrophilin-like protein 2; butyrophylin-like MHC class II associated
Gene Aliases: BTL-II; Btl2; BTLN2; BTN7; BTNL2; Gm315; HSBLMHC1; NG9; SS2