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Invitrogen
BVES Polyclonal Antibody
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FIGURE: 1 / 2
BVES Antibody (PA5-102304) in IHC (P)
Immunohistochemistry analysis of BVES in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with BVES polyclonal antibody (Product # PA5-102304) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102304
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BVES(Accession Q8NE79), corresponding to amino acid residues S174-N224.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total BVES.
Target Information
Blood vessel epicardial substance (BVES), also designated Popeye protein 1, is a transmembrane protein that plays a role in cell-cell interactions and adhesion, specifically at tight junctions. BVES is composed of an extracellular amino-terminus, three transmembrane domains and a cytoplasmic carboxyl-terminus. It is expressed in the developing coronary vascular system, specifically in the proepicardium, migrating epithelial epicardium, delaminated vasculogenic mesenchyme and vascular smooth muscle cells, where it functions to direct development in heart, epithelial and muscle cells during embryogenesis. BVES accumulates at points of cell-cell contact, such as filopodia and cell borders, and promotes adhesion prior to the arrival of E-cadherin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Blood vessel epicardial substance; mBVES; MGC42413; POP 1; POPDC 1; popeye 1; popeye domain-containing 1; Popeye domain-containing protein 1; Popeye protein 1; putative transmembrane protein; unnamed protein product
Gene Aliases: BVES; CARICK; HBVES; LGMD2X; LGMDR25; mBVES; POP1; POPDC1
UniProt ID: (Rat) Q3BCU4, (Mouse) Q9ES83, (Human) Q8NE79
Entrez Gene ID: (Rat) 365603, (Mouse) 23828, (Human) 11149
positive regulation of receptor recycling
regulation of heart rate
hematopoietic progenitor cell differentiation
response to ischemia
cell adhesion
heart development
muscle organ development
skeletal muscle tissue development
regulation of cell shape
striated muscle tissue development
vesicle-mediated transport
substrate adhesion-dependent cell spreading
positive regulation of locomotion
regulation of membrane potential
regulation of GTPase activity
vesicle docking
striated muscle cell differentiation
sinoatrial node cell development
cell migration involved in heart development
epithelial cell-cell adhesion
regulation of endocytic recycling
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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