This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: LNDPTLNDKK AKKLEHQLSL CTQISMLEMR NSIASSSDSD DGLHQFLRGT SSMSSLHVSS PHQRASAKMK PIEEGAEDDD DVFEPASPNT LKVHQLP
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 25%.
Blood vessel epicardial substance (BVES), also designated Popeye protein 1, is a transmembrane protein that plays a role in cell-cell interactions and adhesion, specifically at tight junctions. BVES is composed of an extracellular amino-terminus, three transmembrane domains and a cytoplasmic carboxyl-terminus. It is expressed in the developing coronary vascular system, specifically in the proepicardium, migrating epithelial epicardium, delaminated vasculogenic mesenchyme and vascular smooth muscle cells, where it functions to direct development in heart, epithelial and muscle cells during embryogenesis. BVES accumulates at points of cell-cell contact, such as filopodia and cell borders, and promotes adhesion prior to the arrival of E-cadherin.
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Protein Aliases: Blood vessel epicardial substance; hBVES; MGC42413; POP 1; POPDC 1; Popeye domain-containing protein 1; Popeye protein 1
Gene Aliases: BVES; HBVES; LGMD2X; POP1; POPDC1
UniProt ID: (Human) Q8NE79
Entrez Gene ID: (Human) 11149