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Invovled in activin binding, GPCR kinase activity, serine threonine kinase activity and transforming growth factor beta receptor activity. The role of Baboon (Babo), a type I Activin receptor previously called Atr-I, in Drosophila development and characterize aspects of the Babo intracellular signal-transduction pathway. Genetic analysis of babo loss-of-function mutants and ectopic activation studies indicate that Babo signaling plays a role in regulating cell proliferation. In mammalian cells, activated Babo specifically stimulates Smad2-dependent pathways to induce TGF-beta/Activin-responsive promoters but not BMP-responsive elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activin A receptor 45A; activin type I receptor; babo; babo-PA; babo-PB; babo-PC; baboa; CG8224; CG8224-PA; CG8224-PB; CG8224-PC; G protein-coupled receptor kinase 3; RE55648p; Receptor protein serine/threonine kinase
Gene Aliases: Atf1; ATR-1; ATR-I; Atr45A; AtrI; Bab; BABO; Babo-a; BaboA; CG8224; Dmel\CG8224; Dmel_CG8224; Gprk-3; Gprk3; l(2)44Fd; l(2)k16912; STK-E
Entrez Gene ID: (Fruit fly) 35900
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