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Invitrogen

Bcl-10 Polyclonal Antibody

View all (34) BCL-10 antibodies

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Bcl-10 Polyclonal Antibody

Product Details

PA5-19931

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5 µg/mL
-

Immunocytochemistry (ICC/IF)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A peptide corresponding to amino acids near the amino terminus of human Bcl10.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11157218

Product Specific Information

In Western blot applications, this antibody detects a band at ~31kDa. A suggested positive control is Raji cell lysate.

PA5-19931 can be used with blocking peptide PEP-0056.

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell CLL/lymphoma 10; B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; protein binding; signal transducer activity; R-RCD1; RCD; RP11-234D19.2; unnamed protein product

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Gene Aliases: AI132454; BCL-10; BCL10; c-E10; C81403; CARMEN; cE10; CIPER; CLAP; IMD37; ME10

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UniProt ID: (Human) O95999, (Rat) Q9QYN5, (Mouse) Q9Z0H7

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Entrez Gene ID: (Human) 8915, (Rat) 83477, (Mouse) 12042

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Function(s)
protease binding transcription coactivator activity protein binding kinase activator activity protein binding, bridging ubiquitin protein ligase binding signaling adaptor activity identical protein binding protein kinase B binding macromolecular complex binding CARD domain binding NF-kappaB binding general transcription initiation factor binding protein C-terminus binding transcription factor binding enzyme binding kinase binding protein kinase binding ubiquitin binding protein self-association cysteine-type endopeptidase activator activity involved in apoptotic process protein homodimerization activity protein heterodimerization activity
Process(es)
B cell apoptotic process positive regulation of cytokine production neural tube closure toll-like receptor signaling pathway adaptive immune response immune system process negative regulation of mature B cell apoptotic process apoptotic process cellular defense response response to fungus programmed cell death immunoglobulin mediated immune response positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway response to food response to lipopolysaccharide positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of lymphotoxin A production positive regulation of mast cell cytokine production NIK/NF-kappaB signaling positive regulation of phosphorylation regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription, DNA-templated T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity protein homooligomerization antifungal innate immune response T cell apoptotic process cellular response to lipopolysaccharide cellular response to mechanical stimulus apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway response to molecule of bacterial origin I-kappaB kinase/NF-kappaB signaling cell death positive regulation of cysteine-type endopeptidase activity involved in apoptotic process fibroblast apoptotic process positive regulation of interleukin-8 biosynthetic process protein oligomerization protein heterooligomerization thymocyte apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of JUN kinase activity mast cell activation positive regulation of execution phase of apoptosis
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