The target sequence has 93% sequence homology with porcine, 87% to mouse and 81% to rat. This antibody is not recommended for ICC/IF applications.
Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that heterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: anti-apoptotic Bcl-2 gene family member; Apoptosis regulator Bcl X; Apoptosis regulator Bcl-X; Bcl 2 like 1; Bcl 2 like 1 protein; Bcl xL; BCL XL/S; Bcl-2-like protein 1; Bcl2-L-1; BCL2-like 1; BCL2L1; protein phosphatase 1, regulatory subunit 52
Gene Aliases: Bcl-X; BCL-XL; BCL-XL/S; BCL2L; BCL2L1; BCLX; PPP1R52
UniProt ID: (Human) Q07817
Molecular Function: signaling molecule