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Bcl3 Polyclonal Antibody

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Bcl3 Polyclonal Antibody

Product Details

BS-6591R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Bcl3, amino acids 341-454.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell CLL/lymphoma 3; B-cell CLL/lymphoma 3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3 protein; B-cell lymphoma 3 protein homolog; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; lymphoma 3-encoded protein (bcl-3); Proto-oncogene BCL3; unnamed protein product

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Gene Aliases: AI528691; Bcl-3; BCL3; BCL4; D19S37

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UniProt ID: (Human) P20749, (Mouse) Q9Z2F6

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Entrez Gene ID: (Human) 602, (Mouse) 12051, (Rat) 680611

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Function(s)
transcription cofactor activity transcription coactivator activity transcription corepressor activity protein binding protein binding, bridging histone deacetylase binding DNA-binding transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding membrane traffic protein
Process(es)
negative regulation of cytokine production follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation protein import into nucleus apoptotic process response to stress cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling response to virus response to UV-C positive regulation of gene expression antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production T-helper 1 type immune response defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process T-helper 2 cell differentiation positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade spleen development regulation of DNA binding response to other organism T cell apoptotic process negative regulation of T cell apoptotic process regulation of NIK/NF-kappaB signaling protein import into nucleus, translocation transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of tumor necrosis factor biosynthetic process positive regulation of interleukin-10 biosynthetic process negative regulation of interleukin-8 biosynthetic process regulation of NF-kappaB import into nucleus
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