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Fabgennix

Bcl6 Polyclonal Antibody, FITC

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Bcl6 Polyclonal Antibody, FITC

Product Details

BCL6-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 610-660 on human B-cell lymphoma protein isoform 1.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell CLL/lymphoma 6; B-cell leukemia/lymphoma 5; B-cell leukemia/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein homolog; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; transcriptional repressor; B-cell CLL/lymphoma 6 spliced short isoform; transcriptional repressor; zinc finger protein 51; unnamed protein product; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

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Gene Aliases: Bcl-6; BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51

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UniProt ID: (Human) P41182, (Mouse) P41183

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Entrez Gene ID: (Human) 604, (Rat) 303836, (Mouse) 12053

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding chromatin DNA binding identical protein binding sequence-specific DNA binding metal ion binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding molecular_function nucleic acid binding C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis regulation of cytokine production negative regulation of cell-matrix adhesion plasma cell differentiation immune system process germinal center formation regulation of germinal center formation regulation of immune system process negative regulation of type 2 immune response negative regulation of B cell apoptotic process regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response cellular response to DNA damage stimulus cell-matrix adhesion Rho protein signal transduction spermatogenesis protein localization cell proliferation pyramidal neuron differentiation actin cytoskeleton organization B cell differentiation negative regulation of cell growth positive regulation of B cell proliferation heterochromatin assembly negative regulation of mast cell cytokine production mononuclear cell proliferation negative regulation of mononuclear cell proliferation negative regulation of Rho protein signal transduction type 2 immune response B cell proliferation regulation of cell proliferation regulation of T cell proliferation regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process regulation of memory T cell differentiation T-helper 2 cell differentiation regulation of T cell differentiation positive regulation of regulatory T cell differentiation regulation of cell differentiation positive regulation of cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated isotype switching to IgE isotypes negative regulation of isotype switching to IgE isotypes erythrocyte development cell motility regulation of inflammatory response regulation of immune response positive regulation of lymphocyte activation negative regulation of plasma cell differentiation regulation of leukocyte cell-cell adhesion negative regulation of mitotic cell cycle DNA replication positive regulation of cell motility negative regulation of cellular senescence protein import into nucleus, translocation biological_process negative regulation of cell proliferation positive regulation of histone deacetylation negative regulation of cell differentiation positive regulation of cellular component movement transcription, DNA-templated regulation of transcription, DNA-templated regulation of GTPase activity
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